Fibroblast growth factor receptor 1 gene amplification and protein expression in human lung cancer
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چکیده
منابع مشابه
The Relationship Between Fibroblastic Growth Factor Receptor-1 (FGFR1) Gene Amplification in Triple Negative Breast Carcinomas and Clinicopathological Prognostic Factors
Background & Objective: In Triple-Negative Breast Cancers (TNBCs), estrogen receptor (ER), progesterone receptor (PR) and HER2/neu genes are not expressed. Fibroblastic Growth Factor Receptor-1 (FGFR1) gene product is a protein that acts as a receptor of thyrosin kinase. It plays a role in the proliferation, differentiation, and migration of malignant cells. The objective was t...
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EGFR belongs to the family of structurally and functionally similar ErbB or HER receptors on cell surfaces, which have intracellular tyrosine kinase activity. What all of these receptors have in common is that they consist of extracellular and membrane components to which ligand and intracellular components are bound via the tyrosine kinase activity . Under normal conditions the activity of Erb...
متن کاملFibroblast growth factor receptor-1 protein expression is associated with prognosis in estrogen receptor-positive/human epidermal growth factor receptor-2-negative primary breast cancer.
Recently, research into the development of new targeted therapies has focused on specific genetic alterations to create advanced, more personalized treatment. One of the target genes, fibroblast growth factor receptor-1 (FGFR1), has been reported to be amplified in estrogen receptor (ER)-positive subtype breast cancer, and is considered one possible mechanism of endocrine resistance through cro...
متن کاملFibroblast Growth Factor Receptor 1 Amplification in Non-Small Cell Lung Cancer by Quantitative Real-Time PCR
INTRODUCTION Amplification of the fibroblast growth factor receptor 1 (FGFR1) gene has been described in tumors of non-small-cell lung cancer (NSCLC) patients. Prior reports showed conflicting rates of amplification frequency and clinical relevance. MATERIALS AND METHODS We developed a reliable real-time quantitative PCR assay to assess the frequency of FGFR1 amplification and assessed the op...
متن کاملthe relationship between polymorphic fibroblast growth factor receptor (fgfr) gene and breast cancer risk
background: genetic factors associated with cancer have been widely investigated and several polymorphisms have been connected with breast cancer. breast cancer (bc) can be considered one of the most popular reasons of death among women. bc, likewise, is the second cause of death in iran. the present research aims at determining the frequency of the fibroblast growth factor receptor (fgfr) gene ...
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ژورنال
عنوان ژورنال: Cancer Medicine
سال: 2020
ISSN: 2045-7634,2045-7634
DOI: 10.1002/cam4.2994